Determining the order of DNA building blocks (nucleotides) in an individual's genetic code, called DNA sequencing, has advanced the study of genetics and is one technique used to test for genetic disorders. All five family members underwent whole exome and PCR-free whole genome sequencing. However, until now, the cost of whole-genome sequencing made it inaccessible to … By understanding our genome in its entirety, we are in a better position to outsmart our genes. OGI-081-197 underwent GEDi sequencing as described previously . DNA was extracted from venous blood using the DNeasy Blood and Tissue Kit (Qiagen, Hilden, Germany). Please note that the turnaround time begins from when the sample is received into the lab; This bundle includes the All Panels Package. Each additional time further reduces the error rate, which means that the more times your genome is sequenced (ie the higher the coverage), the more accurate the data will be. The "Whole Genome and Exome Sequencing Markets by Research, Clinical, Tumor, Pathogen, Agribio & Consumer with Executive and Consultant Guides. We listened. 30x is generally preferred when a person is sick. This means that theoretically, genome sequencing data from 0.4x WGS may contain a lot of gaps in the data. For example, genotyping is the technology we use for our Ultimate DNA Test and it’s also the same technology used by 23andMe and AncestryDNA. Includes DNA reports for health, ancestry, and more. Clinical-Grade Whole Genome Sequencing When sequencing … Most often, this involves just sequencing the protein-coding regions of a genome, which reside within DNA segments called 'exons' and reflect the currently 'best understood' part of most genomes. Therefore, we decided to make our reporting highly dynamic and enable user-driven data exploration. Instead, they sequence the DNA in short pieces, around 150 letters long. While the data is generated by a genome sequencing machine is less with 0.4x WGS compared to 30x, applying imputation substantially increases both the quantity and quality of the 0.4x data. Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! 130X coverage for Genome Hotspot Regions, where more than 85% of Known Mutations are incorporated. While most other commercially available DNA tests (e.g. Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. However, until now, the cost of whole-genome sequencing made it inaccessible to most people. Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! How will whole genome sequencing transform disease detection? That’s 6 billion data points for each person’s genome! This enables us to track paternal and maternal ancestry with much greater accuracy. The earliest mention of the 30x paradigm I could find is in the original Illumina whole-genome sequencing paper: Bentley, 2008. If you already have taken a DNA test or have had your genome sequenced, import or upload your data to obtain insights and personalized guidance not available anyplace else. When sequencing is 30x, this means it is clinical-grade. Close. WGS is different from traditional consumer DNA tests known as ‘genotyping’ tests that provide data on part of a person’s genome. Overview of Whole Genome Sequencing (WGS) WGS is the most global approach to identifying genetic variations. Genotyping tests, also know as DNA chips and DNA microarrays, are very affordable (usually less than $100 per test) while also being very accurate, which is why they are excellent alternatives to more expensive whole genome sequencing. Specifically, in Figure 5, they show that most SNPs have been found, and that there are few uncovered/uncalled bases by the time you reach 30x: While all of the apps within the store are a great fit, apps like Wellness & Longevity and Genetic Counseling apps are an excellent starting place. 7 Facts from our Ambry Genetics Review Location: Aliso Viejo, CA Products: clinical DNA testing products that determine the risk of various disease; based on SNP chips, targeted gene sequencing and whole exome sequencing Report delivery: reports are delivered to … Single-cell whole-genome sequencing (WGS) is critical for characterizing dynamic intercellular changes in DNA. For many studies in the Nebula Research Library, we calculate polygenic scores based on your genetic information and help you interpret your scores by comparing them with the scores of other Nebula Genomics users. Order clinical-grade 30x Whole Genome Sequencing and DNA Testing. The cost of whole genome sequencing has been slowly coming down to an affordable level. 30X Whole Genome Sequencing Test £599.00. The reads from the sequencing machine are matched to a ‘reference genome sequence’. Whole GenomeZ – Whole Genome Sequencing for Advanced Analysis (130x + 30x) (starting from $849) This test kit provides 130x coverage of the exome. Health, Wellness, Ancestry, Data Exploration, Health, Rare Diseases, Wellness, Ancestry, Data Exploration. Welcome to Wellspring Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. This extra data processing step makes all the difference. Whole GenomeZ is the preferred test for people facing or seeking diagnosis for Rare and Genetic diseases, utilising higher coverage in coding regions of DNA. Mostly I’m doing this for curiosity and to get familiar with analysis tools, but it seems interesting to get rare variants and maybe worth it to go for 95% sequencing … Turnaround Time: 8 weeks Turnaround Time Quantity description Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. Dante Laboratories had a special offer on their direct-to-consumer (DTC) whole genome service (WGS) in November 2018 when the test was priced at €169 (£150 or $199). Start making conscious health decisions and take a proactive approach to your health. How do I open my BAM file? The Nebula Research Library is a weekly-updated collection of research studies that have been curated by the scientists at Nebula Genomics. 130X coverage for Genome Hotspot Regions, where more than 85% of Known Mutations are incorporated. You can read more about it on the FamilyTreeDNA website here and here. Genotyping is the type of DNA testing used most often, especially when DNA tests are sold online. 30X coverage for the rest of the Genome; Get the most accurate Reports on the market 30X Whole Genome Sequencing Test The most advanced DNA Test on the market Discover 100% of your DNA Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. This type of testing may also be used to create an extensive personalized health plan. Since these files provide your full genome, they Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! For example, your doctor may use the data from clinical-grade WGS to determine what diseases you are genetically predisposed to as well as which medications are best for you to take. For example, 30x is appropriate when a person with a serious yet unknown illness, such as a baby, may have a rare disease. Once a de novogenome has been comple… Their DNA test kits start at $599…which is exactly what you’d pay to get a Nebula Genomics test plus a lifetime subscription. 650 California St | San Francisco, CA | Email: info@nebula.org. In our DNA app store, there are nine categories of apps including health, ancestry, nutrition, fitness, beauty, lifestyle, children, bioinformatics, and clothing. The ancestry reporting will be available in Q2 2020. 30X coverage for the rest of the Genome; Get access to your full genomic data, learn more as science progresses. 130X coverage for Genome Hotspot Regions, where more than 85% of Known Mutations are incorporated. Sequencing.com’s bioinformatics team has also spent a lot of time working with actual data from 0.4x sequencing and what they’ve discovered is amazing. 30X Whole Genome Sequencing Test The most advanced DNA Test on the market Discover 100% of your DNA Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. For example, when you get 30x WGS, the ‘30x’ means that your entire genome will be sequenced an average of 30 times. Whole Genome Sequencing Test is the best lifetime investment: sequence once, get actionable tools for life! Clinical-grade sequencing (30x or higher Proud to come here to BioStars to announce that we're offering 30x whole genome sequencing for $3,490! 30X coverage for the rest of the Genome DNA sequencing machines cannot sequence the whole genome in one go. The accuracy of clinical-grade sequencing can be around 99.99%. The term ‘clinical-grade’ indicates that the genome data is very reliable and, because of this, can be used for health-related purposes. A … The exome is the protein-coding regions of the DNA. 30X Whole Genome Sequencing Test. This is possible because we sequence the entire Y chromosome (for male users) and mitochondrial DNA (for male and female users) and discover all genetic variants that are present. This technology enables our users to benefit from affordable personal genome sequencing without risking their privacy. During the first step, hardware (genome sequencing machines in a laboratory) performs the actual testing and generates the initial genome data. Genotyping tests provide a tremendous amount of useful data for almost everything you’ll want to know about your genes (ancestry, health, medication reactions, wellness, nutrition, fitness, sleep, etc). During the second step, software (computer algorithms) process and greatly enhance the quantity and quality of the genome data. At Sequencing.com, we use MGI DNBSEQ-T7 genome sequencers to provide 150 bp paired-end read 30x whole genome sequencing. You may have seen WGS appear with a number and an ‘x’ before it, such as 0.4x WGS or 30x WGS. Whole Genome Sequencing Test is the best lifetime investment: sequence once, get actionable tools for life! Average 30X Coverage. Our Human Whole Genome products offer the reliability and scalability to produce results you can trust for any size study. 130X coverage for Genome Hotspot Regions, where more than 85% of Known Mutations are incorporated. Skip to main content.sg. 30x whole genome sequencing from Nebula Genomics for $299 The cost of whole genome sequencing has been slowly coming down to an affordable level. Posted by 1 month ago. Ultimate Genome Sequencing includes our Privacy First commitment, which ensures your data is kept confidential and is never sold or shared with anyone. 23andMe and AncestryDNA) read your DNA at about 600,000 positions (~ 0.02%), Whole-Genome Sequencing reads out over 6,000,000,000 positions in … According to the ACLU, “There are at least sixty bills pending in eighteen state legislatures that … Average 30X Coverage Gene By Gene’s whole genome sequencing service allows for a high degree of accuracy in identifying variants across the entire scope of the human genome. Nebula Genomics offers 30x Whole Genome Sequencing. Mapping. The Most advanced … Please note that the turnaround time begins from when the sample is received into the lab; Please note that the turnaround time begins from when the sample is received into the lab; Upon further evaluation, we determined this is because Nebula Genomics applies highly advanced algorithms to the data known as imputation. Prime. 30X Whole Genome Sequencing Test €599.00 EUR. 30X 'Clinical-grade' Whole Genome Sequencing We realized that our users are interested in different things and there is no single reporting that fits everybody. Sequencing was done at the Genomics Core at Massachusetts Eye and Ear as described previously . Our bioinformatics team was initially reluctant to work with data obtained from 0.4x genome sequencing because it is a fairly new concept and they were unsure of the data quality. DNA kits shipped worldwide. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondria and, for plants, in the chloroplast.In practice, genome sequences that are nearly complete are also called whole genome sequences. In fact, there are a few other companies that now offer 30x whole genome sequencing, just like Nebula Genomics — notably Dante Labs and Veritas Genetics. WGS is our most powerful tool for testing for genetic disorders such as mutations that cause rare diseases as well as some forms of cancer. To significantly reduce the potential for errors, most sequencing services will sequence your genome many times! The number before the ‘x’ is the coverage (the average number of times your genome will be sequenced). You can read more about the Nebula Research Library in this blog post and explore the current content of the Nebula Research Library here. 0.4x is generally preferred when a person is healthy. You asked. By offering 30x whole-genome sequencing for $299 we reduced the price more than two-fold. What does that mean? You will always be able to download your genomic data even if you decide to cancel your Nebula Explore subscription. Specifically, in Figure 5, they show that most SNPs have been found, and that there are few uncovered 3. Let’s first take a step back and discuss what whole genome sequencing is and why it’s valuable. For example, 0.4x is appropriate for people who are interested in having their genome sequenced and using the data to improve their health and wellness as well as for ancestry and self-discovery. 30X coverage for the rest of the Genome We give you full access to your genomic data including FASTQ, BAM and VCF files. Incontrast, 30x clinical-grade Whole Genome Sequencing passes through your entire genome approximately 30 times. Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! Our bioinformatics team has determined that the enhanced data obtained from 0.4x WGS is so good that it can be used to obtain both ancestry and health information. When sequencing your genome, there is an important concept known as coverage. Abstract Whole genome sequencing provides the most comprehensive collection of an individual’s genetic variation. While this is a valid concern, many don’t realize that you can always opt-out of genetic research and selling of your genetic data with virtually all companies that offer direct-to-consumer testing. First, it fills in a lot of the gaps and, second, it greatly increases the quality of the data. Nebula Genomics entered the crowded field of DNA testing in 2018, with a single test that encompassed both ancestry and health. The higher the coverage, the better the data quality. WGS has come down significantly in price and, because of this, can now be useful on an everyday basis. Whole genome sequencing (WGS) refers to the comprehensive examination of a genome by reading and stitching together short fragments to determine an organism’s complete chromosomal (nuclear) and mitochondrial DNA sequence. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. The number before the ‘x’ is the coverage (the average number of times your genome will be sequenced). Turnaround Time: 8 weeks Turnaround Time Quantity description Most genetic testing companies analyze less than 0.02% of your DNA, providing very partial information about your genetic makeup. And this year, the company announced that it is now using 30x whole-genome sequencing to analyze customers’ DNA. Let’s first understand what 0.4x means. 30x WGS means that the genome has been sequenced 30 times. In addition to offering the most affordable whole-genome sequencing, we seek to address the mounting concerns over genetic data privacy that have slowed down the growth of the direct-to-consumer genetic testing market. This means the test is repeated 30 times to ensure that the genome is read accurately. Results (raw data only - fastq files) are delivered to the customer via secure FTP … The same applies to genome sequencing. Results (raw data only - fastq files) are delivered to the customer via secure FTP transfer and are only stored by Gene By Gene for 30 … Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. 30x Whole-Genome Sequencing is the gold standard for genetic testing. With the Nebula Research Library, you will be able to stay up to date with the latest research in human genomics and learn how it applies to you. I’m deciding whether to drop another $700 for 100x sequencing ($700 more over the 30x cost). This testing is a lot more comprehensive than that available through other companies.According to Nebula, the majority of direct-to-consumer DNA test kits on the market only decode 0.02% of your DNA. Whole-genome sequencing at 30x coverage accurately reads out over 6 billion letters in the human genome. Both 30x and 0.4x sequencing can be used to generate data that can be used for many purposes. We include 30x WGS with our new Ultimate Genome Sequencing service. Whole-genome sequencing (WGS) is a comprehensive method for analyzing entire genomes. Each of these short sequences is called a ‘read’. Another way to state is this that the genome was sequenced to a depth of 30. Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! Whole genome sequencing provides more detailed and precise data for identifying outbreaks than the current standard technique that PulseNet uses, pulsed-field gel electrophoresis ().Instead of only having the ability to compare bacterial genomes using 15-30 bands that appear in a PFGE pattern, we now have millions of bases to compare. Account & Lists Account Returns & Orders. Gregory A. Hawkins, in Basic Science Methods for Clinical Researchers, 2017. Other DNA Tests only give you limited information based on a fraction of your DNA Cart Hello Select your address Best Sellers Today's Deals Electronics Customer Service Books Home Gift Ideas New Releases Computers Gift Cards Sell. 30X Whole Genome Sequencing Test £599.00. 30x Whole-Genome Sequencing: Amazon.sg: Health & Personal Care. 30X Whole Genome Sequencing Test The most advanced Genetic Test on the market Discover 100% of your DNA Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. Some make the argument that it’s not safe to get sequencing or genotyping from third-party companies because their health data is at risk. WGS is a laboratory technique in which the entire coding (exon) and non-coding (intron) regions of the genome are analyzed. Other DNA Tests only give you limited information based on a fraction of your DNA. Human Whole-Genome Sequencing An overview of Illumina coverage calculation methods using BaseSpace ® or third-party analysis tools. It’s an amazing value that provides you with 100% of your genome and clear solutions for better health. The 15x test currently costs $740. Has anyone weighed the pros and cons? 30x vs 100x whole genome sequencing. I’m deciding whether to drop another $700 for 100x sequencing ($700 more over the 30x cost). There are three core tools. 30x Whole Genome Sequencing Whole Genome Sequencing decodes 100% of your DNA and produces 10,000 times more data than other DNA tests. Those numbers refer to the ‘depth’ of sequencing. Fortunately there are many US Federal and State privacy laws that are protective of privacy. The wide assortment of DNA Analysis Apps at Sequencing.com can analyze any genome sequencing data, including both 0.4x and 30x. Do you test for the MTHFR gene? The more megapixels your camera has, the clearer the image. 30x vs 100x whole genome sequencing. (Including the Whole Genome … Whole genome sequencing is ostensibly the process of determining the complete DNA sequence of an organism's genome at a single time. Other DNA Tests only give you limited information based on a fraction of your DNA. Begin a lifetime of discovery with full access to your genomic data, weekly updates based on the latest scientific discoveries, advanced ancestry analysis, and powerful genome exploration tools. Most other DNA companies only analyze around 2% of your DNA. To their surprise, the genome sequencing provided by Nebula Genomics’ 0.4x WGS was excellent! Dante Laboratories had a special offer on their direct-to-consumer (DTC) whole genome service (WGS) in November 2018 when the test was priced at €169 (£150 or $199). Coverage refers to the number of times the sequencing machine will sequence your genome. This testing is a lot more comprehensive than that available through other companies. Current sample preparation technologies for single-cell WGS are complex, expensive, and suffer from high amplification bias and errors. 30X Whole Genome Sequencing Test €599.00 EUR. There is an additional fee of $600 for a 30x test and a $100 fee for This generates a thousand-fold more information that is also more accurate, enabling more comprehensive reporting on traits and ancestry. We are providing our ancestry reporting in collaboration with FamilyTreeDNA to give our users access to the world’s largest Y chromosome and mitochondrial DNA databases and enable them to connect with relatives. Many of you have asked us questions like that. 30X coverage for the rest of the Genome Get access to your full genomic data, learn more as science progresses. Although Sanger sequencing was used to analyze the first human genome, Sanger sequencing has not developed in scale during the last decade, and thus Sanger sequencing is cost- and time-prohibitive for WGS. $399 for the ultimate clinical-grade 30x Whole Genome Sequencing service. It’s truly the ultimate genetic test that’s available. It’s now also being used for tracking infectious disease outbreaks. WGS may be preferred if the goal is evaluation of rare diseases, such as Cystic Fibrosis and Tay Saches, or if a person simply wants to obtain as much data as possible. It is a new sequencing technology that produces much longer reads which facilitates assembly of repetitive genomic regions. If you are interested in whole genome sequencing (WGS), read on to learn about important considerations. A genetic test that decodes 100% of your DNA with very high accuracy. Genome sequencing technology, including the 30x whole genome sequencing that’s part of our Ultimate Genome Sequencing service, generates data files in bam and fastq formats. Whole Genome Sequencing Test is the best lifetime investment: sequence once, get actionable tools for life! Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement. All international passengers who arrived in India between Dec 9-22 will be subjected to genome sequencing if symptomatic and tested positive for Covid-19. When you see genome sequencing being sold, ‘x’ marks the spot to look for! With a Nebula Explore a subscription you will receive weekly updates based on the latest scientific discoveries, get access to powerful genome exploration tools and learn more about your ancestry than with any other service. 30X Whole Genome Sequencing Test The most advanced Genetic Test on the market Discover 100% of your DNA Empower yourself with the only DNA Test worldwide that analyzes 100% of your DNA. Direct-to-the-consumer whole genome sequencing is available from Thomas Krahn's company YSEQ at 15x, 30x and 50x. Genomic information has been instrumental in identifying inherited disorders, characterizing the mutations that drive cancer progression, and tracking disease outbreaks. Because you have 6 billion letters in your genome, even if the sequencing machine was incredibly accurate 99.99% of the time, the 0.01% error rate means that your genome may have 600,000 errors! 30x Whole-Genome Sequencing is the gold standard for genetic testing. If you haven’t yet taken a DNA test, you can compare DNA tests here. Nebula Genomics is now excited to offer 30x whole-genome sequencing for $299 – a more than a two-fold price reduction. According to Nebula, the majority of direct-to-consumer DNA test kits on the market only decode 0.02% of your DNA. Long read sequencing is done using Oxford Nanopore machines. While most other commercially available DNA tests (e.g. Instead of just 30x whole genome sequencing, our unique service combines the sequencing with advanced bioinformatics analysis as well as several of our top DNA health apps and reports. Nebula Genomics is now excited to offer 30x whole-genome sequencing for $299 – a more than a two-fold price reduction. Gene By Gene’s whole genome sequencing service allows for a high degree of accuracy in identifying variants across the entire scope of the human genome. As many people are purchasing 0.4x WGS from companies such as Nebula Genomics, we’ve started to receive a lot of questions about it. It identifies all major types of genetic changes: ATCG Small sequence changes Structural Variants Mitochondrial variants Short tandem repeat expansions Changing the Way Genetic Testing is Performed Genetic variation is complex, yet … De novo sequencing refers to sequencing a novel genome when a reference or template sequence is not available. Nebula Genomics offers 30x Whole Genome Sequencing. All Hello, Sign in. Our Human Whole Genome products offer the reliability and scalability to produce results you can trust for any size study. Our variant search tool enables you to search your genome for any genetic variant that has been reported in the literature. We bundle our 30x Whole-Genome Sequencing with Nebula Explore, our dynamic reporting service. It provides a comprehensive map of a person’s entire genetic makeup, which consists of nearly 6 billion letters. ... and expand whole genome sequencing … We utilize our own bioinformatics pipeline to analyze raw genetic data, along with BWA-MEM2 The earliest mention of the 30x paradigm I could find is in the original Illumina whole-genome sequencing paper: Bentley, 2008. In our last article, we discussed clinical-grade 30x whole genome sequencing (WGS). Combining the latest sequencing technology with the Broad industry-leading capabilities in process design, automation, and informatics produces the highest quality, most scalable whole genome sequencing available. 130X coverage for Genome Hotspot Regions, where more than 85% of Known Mutations are incorporated. Try. 23andMe and AncestryDNA) read your DNA at about 600,000 positions (~ 0.02%), Whole-Genome Sequencing reads out over 6,000,000,000 positions in your genome (~ 100%). They now offer a 30x whole genome test for €289 (reduced from €599). Nebula Genomics, Partnering with BGI, Sets Industry Standard by Offering 30x Whole-Genome Sequencing for $299 - read this article along with other careers information, tips and advice on BioSpace Nebula Genomics, the leading privacy-focused personal genomics company, today announced a new product at an unmatched price: 30x whole-genome sequencing for $299 in the direct-to … This generates a thousand-fold more information, enabling more comprehensive reporting on traits and ancestry. Includes raw data, bioinformatics analysis, health reports, rare disease screen, ancestry & lifetime private data storage. Transforming genetic testing and personalized medicine Our single method approach uses whole genome sequencing (WGS) to look at your entire DNA. 30X coverage for the So why do some people want whole genome sequencing instead of genotyping? Genotyping genetic tests can obtain data on up to 2 million data points. It is available in 188 countries at an unmatched price of $299. Sequencing reads are assembled as contigs (contiguous consensus sequences from collections of overlapping reads). An alternative to whole-genome sequencing is the targeted sequencing of part of a genome. 130X + 30X Whole GenomeZ: the power of Whole Genome Sequencing, taken further Whole Genome Sequencing & Whole Exome Sequencing, not simply combined, but optimized together! Welcome to Wellspring Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. If you want your genome sequencing to be clinical-grade, make sure it’s 30x. Since reading individual molecules is an extremely difficult task, this makes sure that the machine accurately records each nucleotide in its proper sequence. Similar to genotyping tests and 30x WGS, the enhanced data from 0.4x WGS may also be used to create personalized health plans. 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Methods using BaseSpace ® or third-party analysis tools for 100x sequencing ( WGS ) critical! Analyze around 2 % of your DNA sequences from collections of overlapping reads.. Most global approach to identifying genetic variations called a ‘ read ’ Genomics has a... Sequencing also enables more comprehensive reporting on traits and ancestry offer 30x whole-genome sequencing be... Test worldwide that analyzes 100 % of Known Mutations are incorporated being used for tracking infectious disease.. Test is the best lifetime investment: sequence once, get actionable 30x whole genome sequencing! Includes DNA reports for health, rare Diseases, Wellness, ancestry, Exploration... A. Hawkins, in Basic science methods for Clinical Researchers, 2017 extra data processing and analysis sequencing enables... Facilitates assembly of repetitive genomic Regions ) WGS is the best lifetime investment: sequence once, get actionable for.